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Nattokinase: The Japanese Superfood for a Healthy Diet


Nattokinase: The Japanese Superfood for a Healthy Diet

If you're looking to add nattokinase to your diet, you've come to the right place. This comprehensive guide will tell you everything you need to know about nattokinase, including what it is, its benefits, and how to add it to your diet.

What is Nattokinase and what are its benefits?

According to Japanese legend, around 1000 years ago a man put warm cooked soybeans in a rice-straw sack on the back of his horse and rode off. He didn’t realize that as the sun beat down the soybeans would ferment into a smelly gooey paste that tasted great with white rice. There, Natto was born, which became a staple of the Japanese diet appreciated to contribute to longevity and good health.1,2

The enzyme responsible for Natto’s health effects, Nattokinase, has since been purified and widely studied. Nattokinase keeps blood flow healthy, optimally flowing and promotes overall cardiovascular health. According to research this powerful enzyme can also lower blood pressure 3, 4, it can help reduce the risk of atherosclerosis,5, 6,  help lower lipids, 7 and support optimal blood flow with its anticoagulant properties,8 It is also reported that it may even be neuroprotective. 9 For one single enzyme, it is an impressive list of benefits.

Nattokinase has a unique ability to dissolve fibrin, a protein that helps our body form clots. This is how it performs it magic which has been appreciated for centuries. As we age, we can experience an increase in blood viscosity or thickness. Our own natural clot-dissolving enzymes, which are generated by the cells lining our blood vessels, begin to decline. Thicker blood is more prone to clotting and doesn’t flow as easily through the blood vessels. This can increase blood pressure as the heart has to pump harder to circulate the same amount of blood which then reduces the amount of oxygen and nutrients that reach your organs and tissues. Elevated this thickness contributes to cardiovascular disease, stroke, and dementia.10 

How can you add Nattokinase to your diet for the best results?

Natto is super nutritious. It contains good levels of many nutrients that are important for optimal health. A 3.5-ounce (100-gram) portion provides the following (1):


  • Calories: 212
  • Fat: 11 grams
  • Carbs: 14 grams
  • Fiber: 5 grams
  • Protein: 18 grams
  • Manganese: 76% of the RDI
  • Iron: 48% of the RDI
  • Copper: 33% of the RDI
  • Vitamin K1: 29% of the RDI
  • Magnesium: 29% of the RDI
  • Calcium: 22% of the RDI
  • Vitamin C: 22% of the RDI
  • Potassium: 21% of the RDI 
  • Zinc: 20% of the RDI 
  • Selenium: 13% of the RDI



Natto lovers say that the flavor is an acquired taste. But those that enjoy this food say the extra effort is worth it. It can be pungent and many cannot handle the odor

Most people don't eat natto alone, It is usually consumed on white rice. Some also eat the food on top of toast or pasta. It can also be added to foods including miso soup, salads, or other Japanese dishes such as tamagoyaki (omelet) or okonomiyaki (savory pancake).



Try adding ingredients to natto to enhance the flavor. When sold in Asian convenience stores, mustard and a special Japanese sauce are usually included. You can also add soy sauce, raw egg yolk, chives, green onion, sliced dry bonito, kimchi, wasabi, cheese, mayonnaise, seaweed, peppers, or tuna.

Natto aficionados recommend that you mix the beans thoroughly before eating. When it develops a sticky texture then it is ready to eat.

Nattokinase these days is easily consumed as a supplement. Thai is both easy and also can avoid the ordor if a purified form is used in a white powder form.

Are there any side effects associated with Nattokinase supplementation?

Firstly, let your doctor know of any supplements you're taking or intending to take, even if they're natural. That way, your doctor can check on any potential side effects or interactions with medications.

Nattokinase is likely safe when taken orally in foods. Nattokinase is a natural component of the soy food natto. It has been routinely consumed in Japanese cultures for hundreds of years.

Can Nattokinase interact with certain medications?

Nattokinase is generally safe when taken as a supplement, but it is important to ensure that you are not on additional blood thinners. Discussing this with your doctor is crucial to avoid any potential interactions. Nattokinase has the potential to lower blood pressure in some individuals. If you are currently taking medications for high blood pressure, it is advisable to consult with your doctor before starting Nattokinase. This conversation with your healthcare provider can offer valuable insights and ensure that your blood pressure remains within a healthy range. In fact, this discussion might even present an opportunity to explore the possibility of reducing or discontinuing long-term medication usage. By addressing these concerns with your doctor, you can make informed decisions regarding the use of nattokinase and potentially optimize your overall health. 


Nattokinase might decrease blood pressure in some people. Taking nattokinase along with medications used for lowering high blood pressure might cause your blood pressure to go too low. It is always best discussing with your doctor if you are taking medications for high blood pressure. This could also be an opportunity to get off long term medication.

How much Nattokinase should you take each day for optimal health benefits?

The appropriate dose of nattokinase depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for nattokinase. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

There is no set recommendation for Nattokinase, but studies suggest its health benefits come with an oral dose of 100 to 200 milligrams a day (equivalent to 2,000-4,000 fibrin units [FU])

Is Nattokinase safe for pregnant or breastfeeding women?

Based on the current research available, the safety of nattokinase for pregnant or breastfeeding women remains unclear. Further studies are needed to provide a conclusive answer regarding the safety of nattokinase specifically in these circumstances. Therefore, it is essential for pregnant or breastfeeding women to exercise caution and consult with their healthcare providers before considering the use of nattokinase or any other supplements.

Is Nattokinase safe for people with deep vein thrombosis?

Nattokinase, which possesses blood clot-fighting properties, has the potential to prevent deep vein thrombosis. However, it is crucial to note that using Nattokinase as a treatment for this condition should only be done under the supervision of a medical professional. This is because the rapid dislodgment of a clot by Nattokinase could lead to complications. Therefore, while Nattokinase has the ability to address deep vein thrombosis, it is important to consult with a doctor to ensure its safe and appropriate usage.

Can Nattokinase improve sinus health?

Nattokinase, a naturally occurring enzyme, has been studied for its potential benefits in improving sinus health. Chronic sinusitis, a condition characterized by ongoing inflammation in the sinuses, can be caused by various factors such as allergies, bacterial or fungal infections, or even asthma. This condition is prevalent among adults and can often require surgery to clear nasal passages. Recent research suggests that nattokinase may have positive effects in alleviating chronic sinusitis symptoms. It has been found to aid in shrinking nasal polyps that can obstruct the airways and contribute to congestion. Additionally, the enzyme has shown promise in thinning mucus, which not only improves airflow but also reduces discomfort associated with sinus congestion. Furthermore, nattokinase's potential benefits extend beyond chronic sinusitis. Scientists are actively studying this enzyme for its potential efficacy in treating respiratory conditions such as chronic obstructive pulmonary disease (COPD) and bronchitis. By investigating its effects on these conditions, researchers aim to evaluate whether nattokinase can help manage symptoms and improve respiratory function in individuals suffering from these ailments. Despite ongoing research, it is important to consult with a healthcare professional before incorporating nattokinase or any other supplement into your sinus health routine. They can provide personalized advice and assess whether this enzyme may be beneficial for your specific condition.

What are some of the top Nattokinase supplements on the market today? All available on amazon

It may be difficult to make a decision when searching for the best prostate supplement. With all the various products available, how do you choose? When shopping around for a prostate health supplement, be on the lookout for all of the previously mentioned ingredients. Natural supplements with no additives also make a sensible choice.

  • BoostCeuticals Flow Nattokinase 200mg, Vegan and Pure with no additives
  • Healthy Origins Nattokinase 100mg
  • Doctor's Best Nattokinase 100mg

Conclusion and where to buy best Nattokinase?

Natto is an incredibly nutritious food that’s worth acquiring a taste for.

Eating it regularly may strengthen your immune system and bones, protect you from heart disease and help you digest foods more easily. If you’re planning to taste natto for the first time, start with a small portion, adding plenty of condiments and working your way up gradually.

If you are looking for that easier alternative where you can also control the dosage daily, you will find Nattokinase on Amazon, eBay and Walmart




  1. Nagata C, Wada K, Tamura T, et al. Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study. Am J Clin Nutr. 2017;105:426–431 [Article]
  2. Sumi H, Hamada H, Tsushima H et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43:1110–1111. doi: 10.1007/BF01956052. [Article]
  3. Fujita M, Ohnishi K, Takaoka S et al. Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34:1696–1701 [Article]
  4.  Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008;31:1583–158 [Article]
  5. Ren N, Chen H, Li Y et al. A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia. Nat Med J China. 2017;97:2038–2042. [Article]
  6. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73: 1289–1298 [Article]
  7. Lee MY, Lin CS, Wu DJ. Lipid-Lowering effect of nattokinase in patients with primary hypercholesterolemia. Acta Cardiologica Sinica 2009;25(1) [Article]
  8. Jang JY, Kim TS, Cai J, et al. Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Lab Anim Res. 2013;29:221–225. [Article]
  9. Ji H, Yu L, Liu K, et al. Mechanisms of nattokinase in protection of cerebral ischemia. Eur J Pharmacol. 2014;745:144–151. [Article]
  10. Simmonds MJ, Meiselman HJ, Baskurt OK. Blood rheology and aging. J Geriatr Cardiol. 2013;10(3):291–301. [Article]

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