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The Interesting History of Nattokinase – An Effective Natural Blood Thinner

These days so many individuals are experiencing challenges with their cardiovascular health in relation to poor circulation of blood. This can and often leads to health issues and may even result in heart problems and even serious illness or death. This is a concern for everyone because these problems are becoming more common in the modern world. 

Maybe, this is because of the lifestyle we lead like the type or kind of food we consume or the daily activity or inactivity. Regardless of the reason, one must remember that as people we are prone to poor blood circulation which is a high risk factor for heart and heart-related diseases.

Nattokinase is an enzyme derived from a Japanese food called natto. It was Dr. Hiroyuki Sumi, a Japanese researcher, who discovered Nattokinase. Nattokinase, was discovered as a natural alternative to a better cardiovascular health. The basic idea of the discovery is that, a Japanese soy cheese called Natto was put in an artificial thrombus or, in layman's term, artificial blood clot. The artificial blood clot around the natto was dissolved. On observing this result Dr. Sumi extracted the enzyme responsible for breaking down the artificial blood clot from natto. It was then called Nattokinase, meaning an enzyme from natto.

Nattokinase is an important science based supplement which is an effective natural blood thinner. After the discovery of Nattokinase, it is now years later available in an easy to use capsule form and it is used as an alternative blood thinner for those experiencing problems with their blood flow or those who want to maintain a healthy one. These days it is more common for people looking for medication to also be looking for a more natural choice. Boostceuticals double strength Nattokinase 200 mg helps to maintain a smoother blood flow.

Natto is a traditional and very popular Japanese food dish consumed for centuries in Japanese culture and consists of soy beans which are fermented with a human friendly bacteria Bacillus subtilis after boiling. (Nattokinase is produced by the bacterium acting on the soybeans during the fermentation). The main benefits of natto come from vitamin K2 and Nattokinase. Kinases have a splitting effect and Nattokinase dissolves fibrin which is an essential clotting factor therefore allowing a smoother flow and blood thinning effect. In alternative medicine Nattokinase has been used as a clot dissolver and blood thinner

On the other hand Vitamin K is part of the clotting factor pathway and is a main part of the clotting factor process which prevents excessive bleeding and excessive thinning of blood. Boostceuticals pure Nattokinase enzyme with all vitamin k removed is of value as we age and blood flow changes in our bodies.

The advantage of Boostceuticals formula purified Nattokinase in the form of Soybean Fibrinase Extract 200mg providing 4000 Fibrinolytic Units (not the more common 2000 fu) of activity per capsule is that it offers the positive effects of Nattokinase on its own.

This 200 mg Nattokinase is twice the strength of the more common 100mg Nattokinase supplement.

How is Nattokinase used as medicine?

Nattokinase is commonly used as a medicinal treatment, primarily by adults. It is typically taken orally, with recommended doses ranging from 2000 to 7000 fibrinolytic units per day. This dosage is often administered regularly for a duration of up to three years. 

Should Nattokinase be taken with food or water?

Nattokinase is generally recommended to be taken with food. Taking it with food can help minimize the risk of gastrointestinal discomfort or digestive issues that some individuals may experience when taking supplements on an empty stomach.

Additionally, taking nattokinase with a meal can enhance its absorption and effectiveness because the presence of food in the stomach can stimulate the production of stomach acid and digestive enzymes, which may aid in the breakdown and absorption of the supplement. 

It's also a good practice to take nattokinase with water or another non-alcoholic beverage to ensure that the capsule or tablet is swallowed and reaches the stomach properly. Adequate hydration can further assist with the digestion and absorption of the supplement.

Always follow the specific dosing instructions provided on the product label or the recommendations given by your healthcare provider for the best results.

Is it all natural, safe and how does it work?

Yes, it is naturally occurring and Boostceuticals Nattokinase is made in the USA in an FDA approved facility under GMP known as good manufacturing practices. It is gluten free, soy free and contains no artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, sugar, gluten, starch or wheat.

Nattokinase assists and maintains already normal blood pressure levels and lowers harmful build up in all blood vessels including arteries, veins and capillaries resulting in a smooth blood flow


Here are a few starter tips on using your Nattokinase dietary supplement:

  • For adults, take one (1) capsule daily, preferably with meal and water.
  • Blood can coagulate increasing risk of blood vessel disease. Nattokinese supports healthy blood circulation by dissolving these coagulation effects on blood by maintaining healthier levels of blood clotting factors
  • Boostceuticals high dosage 200mg tablets provide double the dose compared to many which are 100mg and the 200 count is a much larger bottle than the regular 90 or 100 Count. This provides long term maximum benefit and maximum value.
  • Nattokinase from Boostceuticals is a popular enzyme derived from natto a Japanese soy food which contains pure highest strength 4000 FU ( not 2000 FU ) per capsule Nattokinase which helps circulation for optimum health and maintenance of blood pressure levels already within the normal range
  • Not intended for use by pregnant or nursing women. If you are taking any medications or planning any medical procedure, consult your doctor before use. Do not use this product if you are taking anticoagulant (blood thinning medications or have any condition associated with bleeding). Not intended for use by any persons under the age of 18.  

Are there any studies that back this up?

Many clinical studies performed by scientists have shown that Nattokinase supplement supports and benefits a healthy state.

Nattokinase is very popular for individuals frustrated with blood pressure or hypertension, glucose metabolism or risk of blood vessel disease and are looking for some improvement and protection. It is also very popular for individuals looking for a natural solution to their health challenge.

As Nattokinase supports and addresses issues such as the changing physiology of blood vessel walls as we age the supplement can be of significant benefit. In these cases blood thinners can assist in preventing the risk of ill health and which avoid blood restriction and slowing of blood flow. Nattokinase as a science based dietary supplement that can be a more natural way of dealing with these relevant and important modern day life issues.

Are there any studies on the fibrinolytic or thrombolytic effects of nattokinase?

Yes, several studies have investigated the fibrinolytic and thrombolytic effects of Nattokinase. These studies demonstrated that Nattokinase has potent fibrinolytic properties and can enhance thrombolysis, suggesting its potential as a natural alternative for promoting healthy blood clotting and preventing thrombotic events [Fujita et al., 1995; Fujita et al., 1993; Kurosawa et al., 2015].

Are there any studies on the use of Nattokinase for managing atherosclerosis or hyperlipidemia?

Yes, a clinical study involving 1,062 participants examined the use of Nattokinase for managing atherosclerosis and hyperlipidemia. The results showed that Nattokinase was effective in reducing the progression of atherosclerosis and improving lipid profiles [Chen et al., 2022].

Are there any studies on the prevention of venous thrombosis with Nattokinase?

Yes, a randomized, controlled trial called the LONFLIT-FLITE study investigated the use of a nattokinase-based supplement for the prevention of venous thrombosis during long-haul flights. The study found that the supplement, called Flite Tabs, was effective in preventing venous thrombosis [Cesarone et al., 2003].

Are there any studies on the effects of Nattokinase on red blood cell aggregation and whole blood viscosity?

Yes, a study investigated the effects of nattokinase on red blood cell aggregation and whole blood viscosity. The results showed that nattokinase had an impact on these parameters, suggesting its potential role in improving blood flow [Pais et al., 2006].

Are there any specific studies on the effects of Nattokinase on blood pressure?

Yes, a randomized, controlled trial examined the effects of nattokinase on blood pressure. The study found that nattokinase had beneficial effects on blood pressure levels [Kim et al., 2008].

What are the potential side effects of nattokinase?

Nattokinase is generally considered safe when used appropriately. However, like any supplement or medication, it can have potential side effects. Some individuals may experience mild side effects such as gastrointestinal discomfort, diarrhea, or nausea. In rare cases, there have been reports of allergic reactions or an increase in bleeding, particularly in people who are taking blood-thinning medications. If you experience any adverse effects while taking Nattokinase, it's advisable to discontinue use and consult a healthcare professional.

How long can Nattokinase be taken?

The duration for which Nattokinase can be taken may vary depending on individual health goals and needs. Some people take it as a short-term supplement to address specific health concerns, while others incorporate it into their long-term wellness routine. It's crucial to follow the guidance of your healthcare provider, who can recommend the most suitable duration of use based on your health condition and goals.

Does Nattokinase interact with any medications?

Yes, Nattokinase may interact with certain medications. It is important to exercise caution if you are taking anticoagulant or antiplatelet drugs, as Nattokinase has the potential to slow down blood clotting. Combining Nattokinase with these medications might increase the risk of bruising and bleeding. Additionally, if you are taking antihypertensive drugs to manage high blood pressure, Nattokinase may lower your blood pressure further. It is advisable to closely monitor your blood pressure when using both Nattokinase and antihypertensive medications.

Should I consult a healthcare provider before taking nattokinase?

Yes, it is strongly recommended to consult a healthcare provider before starting any new supplement regimen, including Nattokinase. This is especially important if you have existing medical conditions, are taking prescription medications (particularly blood thinners or antiplatelet drugs), or are pregnant or nursing. Your healthcare provider can assess your individual health situation and provide guidance on whether Nattokinase is safe and appropriate for you.

Where can I find additional references or resources on Nattokinase?

If you are looking for additional references or resources on Nattokinase, there are several places you can explore:

1. Scientific Journals: You can search for Nattokinase-related studies and articles in scientific journals like the International Journal of Molecular Sciences, the Journal of Nutritional Biochemistry, or the Journal of Integrative Medicine. These journals often publish research on the effects, mechanisms, and potential benefits of Nattokinase.

2. PubMed: PubMed is a widely-used database for biomedical literature. By searching for "Nattokinase" as a keyword, you can find a range of scientific articles, clinical trials, and reviews related to Nattokinase. This can provide you with a comprehensive understanding of the current research and findings on Nattokinase.

3. Medical Websites: Trusted medical websites like Mayo Clinic, WebMD, and National Institutes of Health (NIH) may have articles or information on Nattokinase. These resources often provide summaries of studies, potential benefits, and safety considerations related to Nattokinase.

4. Books and Book Chapters: Some books and book chapters may delve into the topic of Nattokinase. These resources can provide a more comprehensive understanding of the history, research, and potential applications of Nattokinase.

It's important to note that when researching Nattokinase or any other health-related topic, it is advisable to critically evaluate the information and consider the credibility and relevance of the sources. Additionally, consulting with a healthcare provider or medical professional can provide personalized guidance and recommendations based on your specific needs and health condition.



*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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